Combined assignment and dynamics algorithm for NMR applications

CYANA (© by Peter Güntert) is a program for automated structure calculation of biological macromolecules on the basis of conformational constraints from NMR. The combination of automated NOESY cross peak assignment, structure calculation with a fast torsion angle dynamics algorithm, and the ease-of-use of CYANA provide for unprecedented efficiency in NMR protein structure determination.

Cyana Mailing List Registration
The CYANA Wiki

Information about CYANA

System requirement

CYANA is available exclusively from LAS. The current version is CYANA 2.1.
System requirements for CYANA 2.1

  • CYANA 2.1 has been tested on the following Linux/Unix systems:
    • Linux Redhat 9 (Intel 8.1 Fortran compiler)/Ubuntu/CentOS
    • Compaq Alpha
    • IBM AIX
    • Silicon Graphics IRIX
    • Mac OS X (64 bit)
    • Windows XP using Cygwin and the g95 Fortran compiler
  • Binaries are available for the following Unix/Linux systems.
    In case of problems, the program must be compiled from source.
    • Linux (Redhat 9/Fedora Core 4/Ubuntu/CentOS)
    • Mac OS X
  • For compilation: Intel Fortran compiler or gfortran
  • For parallel calculations on distributed-memory systems: OpenMPI

How to Purchase

To obtain a CYANA software license, please follow these steps:

1, Download the License form file for CYANA 2.1.

  • The License form files are followings:
    academic [PDF:17KB]
    commercial [PDF:15KB]
  • An academic user is an individual or a single research group. An academic user should not use the software for any purpose (research or otherwise) supported by a "for profit" or military organization.
  • Organizations, e.g. computer centers, that will give access to the software to more than one academic research group need a special license. All other users need a Commercial License.
  • Licenses include the source code, are unlimited in time.
  • Licenses can be used simultaneously on any number of computer systems at the site of the licensee.

2, Print and fill out the License form(Type or clearly print).

  • The completed and duly signed form and your purchase order form can be sent by email to, or sent by mail to the following address:

         L. A. Systems, Inc.
         1-17-1 Sengen
         Tsukuba Ibaraki 305-0047

3, We will send the invoice by e-mail.

    Software Package Academic License Commercial License
    CYANA 2.1 700 Euro 15,000 Euro
  • The acceptable method of payment is wire transfer by pay in EURO. Do not accept Credit Card and Check.
  • Do not change in other foreign currency. If you are not able to pay in EURO, please contact us.
  • Please pay the bank's charges, taxes if any, on Applicant. Price of a tax refund like VAT cannot be performed.

4, Upon receipt of the payment, we will e-mail you the ID and password for login to the CYANA download site.

  • It takes about two weeks or more to issue the license after the wire transfer.
  • The current version is CYANA 2.1 released in July 2005. The upgrade from earlier Cyana (not Dyana) versions is free-of-charge. If you are interested in the upgrade, please contact us.

Mailing List

Please register to the Cyana Mailing List.
This is not automatic approval. The completion notice is delivered from LAS Support in several days.
Please contact us if you have any questions. (E-mail :


  • Güntert, P., Mumenthaler, C. & Wüthrich, K. (1997). Torsion angle dynamics for NMR structure calculation with the new program DYANA. J. Mol. Biol. 273, 283-298.
  • Any reports or publications of results obtained with CYANA must cite this paper.
  • Herrmann, T., Güntert, P. & Wüthrich, K. (2002). Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA. J. Mol. Biol. 319, 209-227.
  • Any reports or publications of results obtained with the CANDID module of CYANA must acknowledge the use of CANDID by citing this paper.
  • Güntert, P. (2003). Automated NMR protein structure calculation. Prog. NMR Spectrosc. 43, 105-125.
  • Güntert, P. (2004). Automated NMR protein structure calculation with CYANA. Meth. Mol. Biol. 278, 353-378.
  • Jee, J. G. & Güntert, P. (2003). Influence of the completeness of chemical shift assignments on NMR structures obtained with automated NOE assignment. J. Struct. Funct. Genom. 4, 179-189.

All CYANA-related publications is here.

[Back to top of page]